General description of research project: Peritoneal Tissue Repair and Adhesion Prevention Studies on tissue repair have largely focused on dermal healing. The present project focuses on tissue repair in peritoneum. The healing of peritoneum differs from that of the skin in that peritoneum may regenerate.If this healing process is perturbed tissue repair becomes excessive, leading to the formation of adhesions which may impair the function of the internal organs. Based on our previous findings of a significant and rapid decline of plasminogen activating activity during surgery, and in conditions associated with a subsequent development of adhesions, we hypothesize that excessive tissue repair in peritoneal cavity is caused by a decreased expression of plasmin, and that its expression is modulated by cytokines.